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Intrinsic Disruption of the M1 Cortical Network in a Mouse Model of Parkinson's Disease

Background Parkinson's disease (PD) disrupts motor performance by affecting the basal ganglia system. Yet, despite the critical position of the primary motor cortex in linking basal ganglia computations with motor performance, its contribution to …

Whole-organism behavioral profiling reveals a role for dopamine in state-dependent motor program coupling in C. elegans

Animal behaviors are commonly organized into long-lasting states that coordinately impact the generation of diverse motor outputs such as feeding, locomotion, and grooming. However, the neural mechanisms that coordinate these diverse motor programs …

Rapid, Inexpensive Measurement of Synthetic Bacterial Community Composition by Sanger Sequencing of Amplicon Mixtures

Stimjim: open source hardware for precise electrical stimulation

textlessptextgreaterElectrical stimulation is a simple and powerful tool to perturb and evoke neuronal activity in order to understand the function of neurons and neural circuits. Despite this, devices that can provide precise current or voltage …

Rapid and high-precision sizing of single particles using parallel suspended microchannel resonator arrays and deconvolution

Modular Assembly of Polysaccharide-Degrading Marine Microbial Communities

Summary Understanding the principles that govern the assembly of microbial communities across earth’s biomes is a major challenge in modern microbial ecology. This pursuit is complicated by the difficulties of mapping functional roles and …

Optofluidic real-time cell sorter for longitudinal CTC studies in mouse models of cancer

Despite the usefulness of genetically engineered mouse models in cancer research, their small total blood volume and the rarity of circulating tumor cells (CTCs) preclude the use of existing liquid biopsy techniques for longitudinal CTC studies in …

Linking single-cell measurements of mass, growth rate, and gene expression

Mass and growth rate are highly integrative measures of cell physiology not discernable via genomic measurements. Here, we introduce a microfluidic platform enabling direct measurement of single-cell mass and growth rate upstream of highly …

Direct single-cell biomass estimates for marine bacteria via Archimedes' principle

Microbes are an essential component of marine food webs and biogeochemical cycles, and therefore precise estimates of their biomass are of significant value. Here, we measured single-cell biomass distributions of isolates from several numerically …

Drug sensitivity of single cancer cells is predicted by changes in mass accumulation rate

Assays that can determine the response of tumor cells to cancer therapeutics could greatly aid the selection of drug regimens for individual patients. However, the utility of current functional assays is limited, and predictive genetic biomarkers are …