Catalytic Domain

Inhibition of secreted phospholipases A2 by 2-oxoamides based on $α$-amino acids: Synthesis, in vitro evaluation and molecular docking calculations

Group IIA secreted phospholipase A2 (GIIA sPLA₂) is a member of the mammalian sPLA₂ enzyme family and is associated with various inflammatory conditions. In this study, the synthesis of 2-oxoamides based on $α$-amino acids and the in vitro evaluation …

Simplified YM-26734 inhibitors of secreted phospholipase A2 group IIA

Simplified analogs of YM-26734, a known inhibitor of secreted phospholipase A(2) (sPLA(2)) group IIA, were synthesized and found to also display potent inhibition at low nanomolar concentrations. Analogs were based on the didodecanoylphloroglucinol …