Pyridines

Inhibition of secreted phospholipases A2 by 2-oxoamides based on $α$-amino acids: Synthesis, in vitro evaluation and molecular docking calculations

Group IIA secreted phospholipase A2 (GIIA sPLA₂) is a member of the mammalian sPLA₂ enzyme family and is associated with various inflammatory conditions. In this study, the synthesis of 2-oxoamides based on $α$-amino acids and the in vitro evaluation …